Can I Connect a x4 PCIe board into an x16 PCIe Slot? - NI

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168 slot online I have a very simple question: will a PCI Express x16 graphics card work in a PCIe x16 slot? I'm not sure about the  PCIe boards can fit into slots designed for their lane configuration or higher Plugging a x4 PCIe into a x16 slot is acceptable